Fecal immunochemical test for hemoglobin in combination with fecal transferrin in colorectal cancer screening
نویسندگان
چکیده
منابع مشابه
Colorectal cancer detection in an asymptomatic population: fecal immunochemical test for hemoglobin vs. fecal M2-type pyruvate kinase.
INTRODUCTION Screening programs for colorectal cancer (CRC) are mainly based on a first-line fecal immunochemical test for hemoglobin (FIT). Fecal M2-type pyruvate kinase (M2-PK) has been evaluated in clinical settings showing promising results for early CRC detection. However, the impact of fecal M2-PK assessment on the performance of first-round CRC screening programs is not known. We investi...
متن کاملImmunochemical fecal occult blood tests for colorectal cancer screening.
BACKGROUND The superiority of several immunochemical fecal occult blood tests (I-FOBT) over guaiac-based tests in colorectal cancer screening is now established. The aim of this study was to compare the analytical performance of 3 quantitative I-FOBTs. METHODS Stool samples from 10 healthy volunteers, initially I-FOBT negative, supplemented with human blood, were used to compare reproducibili...
متن کاملFecal DNA for noninvasive diagnosis of colorectal cancer in immunochemical fecal occult blood test-positive individuals.
BACKGROUND We aimed to define the potential of the fecal DNA assay as an alternative or in addition to the currently used immunochemical fecal occult blood test (iFOBT) for the early diagnosis of colorectal cancer. METHODS A total of 560 individuals aged 50 to 69 years with a positive iFOBT were recruited from an Italian FOBT regional screening program. Twenty-six were diagnosed with adenocar...
متن کاملSelecting a Cut-off for Colorectal Cancer Screening With a Fecal Immunochemical Test
OBJECTIVES Fecal immunochemical tests (FITs) for hemoglobin (Hb) are increasingly used for colorectal cancer (CRC) screening. However, cut-offs for defining test positivity are varying widely. We aimed to evaluate the impact of cut-off selection on key indicators of diagnostic performance in a true screening setting. METHODS We evaluated diagnostic performance of FOB Gold, a widely used quant...
متن کاملClinical impact of the immunochemical fecal occult blood test for colorectal cancer screening in Brazil
BACKGROUND Colorectal cancer (CRC) screening programs based on the fecal occult blood test (FOBT) reduce CRC mortality. We carried out an observational prospective study to determine the accuracy of immunochemical FOBTs for the detection of CRC in individuals at average risk for the disease. METHODS This population-based study was performed between April 2015 and January 2016 in two gastroent...
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ژورنال
عنوان ژورنال: United European Gastroenterology Journal
سال: 2018
ISSN: 2050-6406,2050-6414
DOI: 10.1177/2050640618784053